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Quinoline, Coumarin and Other Heterocyclic Analogs Based HIV-1 Integrase Inhibitors

[ Vol. 15 , Issue. 1 ]

Author(s):

Pankaj Wadhwa, Priti Jain, Santosh Rudrawar and Hemant R.A. Jadhav*   Pages 2 - 19 ( 18 )

Abstract:


Human Immunodeficiency Virus Type 1 Integrase or HIV-1 integrase (IN) is a 288 amino acid protein that incorporates the retrotranscribed viral DNA into the host chromosomal DNA. Over the past 30 years, large number of derivatives have been evaluated for their inhibitory potential against IN. There is vast literature available which need to be collated to help scientists plan the future drug design. This review discusses the reports of past 25 years on analogs of quinoline, coumarin and other related heterocycles, which exhibit low micromolar inhibitory potency against IN.

Keywords:

HIV-1 integrase, quinolines, coumarins, strand transfer inhibitors, 3'-end processing inhibitors, heterocyclic analogs.

Affiliation:

Department of Pharmacy, Birla institute of Technology and Science Pilani, Pilani Campus, Pilani- 333031, Rajasthan, Department of Pharmacy, Birla institute of Technology and Science Pilani, Pilani Campus, Pilani- 333031, Rajasthan, Menzies Health Institute Queensland, Griffith University, Gold Coast 4222, Department of Pharmacy, Birla institute of Technology and Science Pilani, Pilani Campus, Pilani- 333031, Rajasthan

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