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Drug Stereochemistry: A Prodigy For Pharmacology and Drug Development

Author(s):

Karan Gandhi, Umang Shah* and Sandip Patel   Pages 1 - 9 ( 9 )

Abstract:


Stereochemistry has evinced the importance of many chiral drugs in aspects of drug designing and development. A literature review was conducted for several chiral drugs involving pharmacokinetic and pharmacodynamic parameters of their enantiomers along with their uses in certain diseased conditions. This article generally includes the pharmacological profile review of some chiral drugs and the aspects by which the single enantiomer can be of significant importance as compared to the racemic mixture of the drug. This can be achieved either by assuaging the side effects or toxic effects; or by the potentiated activity of the single enantiomer. Resolution deals with the separation of racemic compounds which shows up the credibility to obtain the desired enantiomeric properties. As isomers vary in their pharmacokinetic and pharmacodynamic profiles, chiral drugs have showcased considerable importance in the drug development process. Both enantiomers have a different pharmacological profile in the treatment of a disease, which differentiates them from drug racemates.

Keywords:

Stereochemistry, Resolution, R and S Enantiomer, Pharmacological Profile, Racemates

Affiliation:

Faculty of Pharmacy, Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology, Charusat campus, Changa, Gujarat, Department of Pharmaceutical Chemistry, Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology, Charusat campus, Changa, Gujarat, Department of Pharmacology, Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology, Charusat campus, Changa, Gujarat



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