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Review of Phytochemical Compounds as Antiviral Agents Against Arboviruses from the Genera Flavivirus and Alphavirus

[ Vol. 17 , Issue. 4 ]


Samira Sardari, Mahmoud Rafieian-Kopaei*, Khojasteh Malekmohammad and Robert D.E. Sewell   Pages 484 - 497 ( 14 )


Arboviruses are a diverse group of viruses that are among the major causes of emerging infectious diseases. Arboviruses from the genera flavivirus and alphavirus are the most important human arboviruses from a public health perspective. During recent decades, these viruses have been responsible for millions of infections and deaths around the world. Over the past few years, several investigations have been carried out to identify antiviral agents to treat these arbovirus infections. The use of synthetic antiviral compounds is often unsatisfactory since they may raise the risk of viral mutation; they are costly and possess either side effects or toxicity. One attractive strategy is the use of plants as promising sources of novel antiviral compounds that present significant inhibitory effects on these viruses. In this review, we describe advances in the exploitation of compounds and extracts from natural sources that target the vital proteins and enzymes involved in arbovirus replication.


Arbovirus, flavivirus, alphavirus, antiviral, natural compounds, plant products.


Department of Pathobiology, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Department of Animal Sciences, Faculty of Basic Sciences, Shahrekord University, Shahrekord, Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, CF10 NB. Wales

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