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Current Development on Chitosan-based Antimicrobial Drug Formulations for the Wound Healing

[ Vol. 17 , Issue. 4 ]

Author(s):

Harekrishna Roy*, Shaik A. Rahaman, Theendra V. Kumar and Sisir Nandi*   Pages 534 - 541 ( 8 )

Abstract:


Background: Derived from polyose, chitosan is an outstanding natural linear polysaccharide comprised of random arrangement of β-(1-4)-linked D-Glucosamine and N-acetyl-DGlucosamine units.

Objective: Researchers have been using chitosan as a network forming or gelling agent with economically available, present polyose, low immunogenicity, biocompatibility, non-toxicity, biodegradability, protects against secretion from irritation and don’t suffer the danger of transmission animal infective agent.

Methods: Furthermore, recent studies gear up the chitosan used in the development of various biopharmaceutical formulations, including nanoparticles, hydrogels, implants, films, fibers, etc.

Results: These formulations produce potential activities as antimicrobials, cancer treatment, medical aid, and wound healing, controlled unleash device or drug trigger retarding device and 3DBiomedical sponge, etc.

Conclusion: The present article discusses the development of various drug formulations utilizing chitosan as biopolymers for the repairing of broken tissues and healing in case of wound infection.

Keywords:

Natural linear polysaccharide, chitosan, films, hydrogels, nanoparticles, fibers, implant coatings, wound care.

Affiliation:

Department of Pharmaceutics, Nirmala College of Pharmacy, Affiliated to Acharya Nagarjuna University, Guntur, Andhra Pradesh, Department of Pharmaceutics, Nirmala College of Pharmacy, Affiliated to Acharya Nagarjuna University, Guntur, Andhra Pradesh, Department of Pharmaceutics, Nirmala College of Pharmacy, Affiliated to Acharya Nagarjuna University, Guntur, Andhra Pradesh, Department of Pharmaceutical Chemistry, Global Institute of Pharmaceutical Education and Research, Affiliated to Uttarakhand Technical University, Kashipur-244713

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