Meysam Shirzad, Mohammad Mahdi Ahmadian-Attari, Seyed Mohammad Sadegh Ghafoori, Leila Mohammad Taghizadeh Kashani , Mehdi Pasalar, Alireza Abbassian and Shahram Agah * Pages 1 - 7 ( 7 )
Background: Ulcerative Colitis (UC) is a chronic condition that represents a group of intestinal disorders causing prolonged inflammation of the digestive tract. Nowadays, efforts to investigate new remedies have led to a committed movement which tries for the integration of traditional and complementary medicine into the mainstream medicine. In Traditional Persian Medicine (TPM), Maqliasa is one of the most frequent gastrointestinal prescriptions which is claimed to be effective in both remission and recurrent phases of UC.
Objective: The aim of this pilot study was to examine the effect of Maqliasa on UC symptoms.
Methods: Through a non-randomized before-after uncontrolled clinical trial, 13 outpatients with active UC were enrolled in the study. They continued their conventional drug regimens plus Maqliasa capsules (2 capsules t.i.d.) for 28 days. Three visits were arranged for each patient− the first admission, day 14th admission and day 28th admission. The patients were evaluated by Lichtiger Colitis Activity Index. Wilcoxon signed-rank test was used for statistical analysis.
Results: The Lichtiger colitis activity index improved in the study group was compared to the corresponding baseline values: baseline score: 7.8 ± 0.5; after two weeks: 5.9 ± 0.6 (P=0.002); after four weeks: 3.6 ± 0.5 (P=0.001).
Conclusions: This study showed the promising effect of Maqliasa in the treatment of active UC. However, due to some of the limitations of the study, conducting future high-quality randomized clinical trials would be crucial.
HDL, CETP, clinical outcomes, endothelial function, Inflammatory Bowel Disease, Ulcerative Colitis, Persian Medicine, Gastroenterology, Herbal Medicine, Clinical Trial
Department of Persian Medicine, School of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Evidence-Based Phytotherapy and Complementary Medicine Research Center, Alborz University of Medical Sciences, Karaj, Colorectal Research Center, Iran University of Medical Sciences, Tehran, Department of Traditional Medicine, Medicinal Plants Research Center of Barij, Kashan, Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Department of Persian Medicine, School of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Colorectal Research Center, Iran University of Medical Sciences, Tehran