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Pharmacological Applications of Phlorotannins: A Comprehensive Review

Author(s):

Ahsan Javed*, Muhammad Bilal Hussain, Ali Tahir, Marwa Waheed, Ahsan Anwar, Mohammad Ali Shariati, Sergey Plygun, Alexey Laishevtcev and Mehdi Pasalar*   Pages 1 - 11 ( 11 )

Abstract:


Background: Seaweeds including marine brown algae are traditional food sources in Asia. Phlorotannins, as the product of polyketide pathway, are mainly found in brown algae. Different properties have been attributed to this group of marine products ranging from anti-allergic to anticancer activity. Mechanism of action is not obvious for all these properties, but there are some explanations for such effects.

Objective: The aim of the current study was to review the phlorotannins and to assess the beneficial uses in medicine.

Methods: Different databases were explored with the exact terms “Phlorotannin”, “Seaweed” and “Brown Algae”. Data assembly was finalized by June 2019. The papers showing the effects of phlorotannins in medicine were gathered and evaluated for further assessment.

Results: General physiological aspects of phlorotannins were firstly evaluated. Different arrays of pharmacological properties ranging from anti-diabetic activity to cancer treatment were found. The mechanism of action for some of these beneficiary properties has been confirmed through rigorous examinations, but there are some features with unknown mechanisms.

Conclusion: Phlorotannins are characterized as a multifunctional group of natural products. Potential antioxidant characteristics could be attributed to preventive and/or their curative role in various diseases.

Keywords:

Phlorotannins, Seaweed, Marine, Brown algae, Polyphenol, Antioxidant

Affiliation:

Institute of Home and Food Sciences, Government College University, Faisalabad, Institute of Home and Food Sciences, Government College University, Faisalabad, Institute of Home and Food Sciences, Government College University, Faisalabad, Institute of Home and Food Sciences, Government College University, Faisalabad, Institute of Home and Food Sciences, Government College University, Faisalabad, Laboratory of Biological Control and Antimicrobial Resistance, Orel State University named after I.S. Turgenev, Orel City, 302026, Laboratory of Biological Control and Antimicrobial Resistance, Orel State University named after I.S. Turgenev, Orel City, 302026, Laboratory of Biological Control and Antimicrobial Resistance, Orel State University named after I.S. Turgenev, Orel City, 302026, Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz



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