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Prunella vulgaris L: Critical Pharmacological, Expository Traditional Uses and Extensive Phytochemistry: A Review

Author(s):

Reyaz Hassan Mir, Mohammad Faizan Bhat, Gifty Sawhney, Parveen Kumar, Nusrit Iqbal Andrabi, Majeed Shaikh, Roohi Mohi-ud-Din and Mubashir Hussain Masoodi*   Pages 1 - 13 ( 13 )

Abstract:


Background: Prunella vulgaris, family Lamiaceae also known as self-heal, has been traditionally used as an expectorant, anti-inflammatory, anti-pyretic, and anti-rheumatic. Due to widespread distribution of the plant, Vulgaris is also called ‘vulgar’ in Latin adjective meaning common.

Objective: The objective of this review was to describe the relevant aspects of phytochemistry and therapeutic uses of different fractions as well as isolated compounds from Prunella vulgaris. An attempt was also made to enumerate the possible leads e.g. betulinic acid, oleanolic acid, ursolic acid, umbelliferone, scopoletin, esculetin, luteolin, homoorientin, Rosmarinic acid and cinaroside for further development.

Method: For peer-reviewed research literature, we undertook a structured search of bibliographic databases using a focused review question. Scientific databases such as PubMed, Scopus, Science Direct, and Google Scholar were used

Results: Phytochemistry of Prunella vulgaris (PV) after a thorough literature survey revealed varied and copious metabolites, such as triterpenoids, phenolic acid, sterols, carbohydrates, coumarins, fatty acids, and volatile oils. Many of these compounds have been found to possess wide range of biological activity per se, including anti-microbial, immunosuppressive, anti-cancer, cardio-protective, anti-allergic and anti-inflammatory.

Conclusion: Prunella vulgaris is a medicinal plant of immense medicinal importance having a variety of compounds such as such as triterpenoids, phenolic acid, sterols, carbohydrates, coumarins, fatty acids, and volatile oils and diversity in pharmacological spectrum. The plant could be further exploited, to isolate the various biologically active constituents responsible for its activity.

Keywords:

Prunella vulgaris, phytochemistry, cytotoxicity antimicrobial, immunosuppressive, anticancer, cardioprotective,

Affiliation:

Pharmaceutical Chemistry Division, Department of Pharmaceutical Sciences, University of Kashmir, Hazratbal, Srinagar-190006, Kashmir, Pharmaceutical Chemistry Division, Groningen Research Institute of Pharmacy, , Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi, 180001 Kashmir, Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi, 180001 Kashmir, Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi, 180001 Kashmir, Natural Product Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi, 180001 Kashmir, Pharmacognosy and Phytochemistry Lab, Department of Pharmaceutical Sciences, School of Applied Sciences and Technology, University of Kashmir, Hazratbal, Srinagar-190006, Kashmir., Pharmaceutical Chemistry Division, Department of Pharmaceutical Sciences, University of Kashmir, Hazratbal, Srinagar-190006, Kashmir



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